Fast temperature regulation for cell biology imaging : publications

Origin of the TempoCell™ fast temperature regulator for cell biology imaging

The first prototype of this fast temperature regulation system was validated in collaboration with UPENN (USA) and Institute Curie (France). Since the first release of the fast temperature regulator, performances, biological and user compliance have been optimized* to enable the ease of use for cell biology experiments on microscope. During the beta testing of the TempoCell™ system, several scientific publications in cell biology certify the power of such a tool for biology.

*For more information about the performances of our fast temperature regulator for cell biology imaging system: click here

Biological proof of concept validating TempoCell™ fast temperature regulation system for cell biology

The TempoCell™ fast temperature regulation system has been optimized for high resolution imaging in cell biology research. The ability of the TempoCell™ temperature regulator to quickly modify the temperature of the biological sample under microscope observations has been applied to cytoskeleton polymerization. The compatibility of the TempoCell™ temperature regulation system with high resolution microscopy enabled to study the polarity in fission yeast and mitochondria positioning. The fastness of the TempoCell™ temperature regulation system has been also applied for thermosensitive proteins activation during imaging of cell on microscope.

Publications validating the TempoCell™ fast temperature regulation system for cell biology

• Fast temperature regulator for mitochondria  positioning on microscope (abstract of  ”mmb1p Binds Mitochondria to Dynamic Microtubules”, Current Biology, 2011)
• Fast temperature regulator for cytoskeleton studies on microscope (full text of  ”Cytoskeleton studies on fission yeast : A fast temperature regulator for cell biology imaging”, METHODS IN CELL BIOLOGY, 2010)
• Fast temperature control for thermosensitive protein regulation (full text of “Phospho-Regulated Interaction between Kinesin-6 Klp9p and Microtubule Bundler Ase1p Promotes Spindle Elongation”, Developmental Cell, 17, 2, 257-267, 18 August 2009)
• Fast microfluidic temperature  control for high resolution live cell imaging  (full text of “Fast microfluidic temperature control for high resolution live cell imaging”, Lab Chip, 2011 )

If you want to learn more about the technological core of TempoCell™ you can learn more about microfluidic here.